Innate Immunity and Cellphones for Patient Care
Basic research interests include innate immune mechanisms of susceptibility to infectious diseases, the role of innate immunity in vaccine design, and the control of inflammation and its role in HIV pathogenesis.
Clinical research interests include using mobile information technology (cell phones) to improve patient support and health services in resource-limited settings. This work was featured on CBC’s, The National.
Thirumurthy H, Lester RT. M-health for health behaviour change in resource-limited settings: applications to HIV care and beyond. Bull World Health Organ 2012; 90(5):390-392.
Mills EJ, Lester R, Ford N. Adherence to antiretroviral therapy: supervision or support? Lancet Infect Dis 2012; 12(2):97-98.
Mills EJ, Lester R, Ford N. Promoting long term adherence to antiretroviral treatment. BMJ 2012; 344:e4173.
Mills EJ, Wu P, Alberton M, Kanters S, Lanas A, Lester R. Low-dose aspirin and cancer mortality: a meta-analysis of randomized trials. Am J Med 2012; 125(6):560-567.
Mbuagbaw L, Thabane L, Ongolo-Zogo P, Lester RT, Mills E, Volmink J et al. The Cameroon mobile phone SMS (CAMPS) trial: a protocol for a randomized controlled trial of mobile phone text messaging versus usual care for improving adherence to highly active anti-retroviral therapy. Trials 2011; 12:5.
Karanja S, Mbuagbaw L, Ritvo P, Law J, Kyobutungi C, Reid G et al. A workshop report on HIV mHealth synergy and strategy meeting to review emerging evidence-based mHealth interventions and develop a framework for scale-up of these interventions. Pan Afr Med J 2011; 10:37.
Lester RT, Ritvo P, Mills EJ, Kariri A, Karanja S, Chung MH et al. Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. Lancet 2010; 376(9755):1838-1845.
Eyawo O, de Walque D, Ford N, Gakii G, Lester RT, Mills EJ. HIV status in discordant couples in sub-Saharan Africa: a systematic review and meta-analysis. Lancet Infect Dis 2010; 10(11):770-777.
McKinnon LR, Kimani M, Wachihi C, Nagelkerke NJ, Muriuki FK, Kariri A et al. Effect of baseline HIV disease parameters on CD4+ T cell recovery after antiretroviral therapy initiation in Kenyan women. PLoS One 2010; 5(7):e11434.
Lester RT, Mills EJ, Kariri A, Ritvo P, Chung M, Jack W et al. The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol. Trials 2009; 10:87.
Lester RT, Jaoko W, Plummer FA, Kaul R. Sex, microbial translocation, and the African HIV epidemic. Proc Natl Acad Sci U S A 2009; 106(34):E89.
Lester RT, Yao XD, Ball TB, McKinnon LR, Omange WR, Kaul R et al. HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers. PLoS One 2009; 4(5):e5644.
Lester R, Karanja S. Mobile phones: exceptional tools for HIV/AIDS, health, and crisis management. Lancet Infect Dis 2008; 8(12):738-739.
Lester RT, Yao XD, Ball TB, McKinnon LR, Kaul R, Wachihi C et al. Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection. AIDS 2008; 22(6):685-694.
Lester RT, Gelmon L, Plummer FA. Cell phones: tightening the communication gap in resource-limited antiretroviral programmes? AIDS 2006; 20(17):2242-2244.
Lester R, Li C, Phillips P, Shenkier TN, Gascoyne RD, Galbraith PF et al. Improved outcome of human immunodeficiency virus-associated plasmablastic lymphoma of the oral cavity in the era of highly active antiretroviral therapy: a report of two cases. Leuk Lymphoma 2004; 45(9):1881-1885.
Lester RT, McGeer A, Tomlinson G, Detsky AS. Use of, effectiveness of, and attitudes regarding influenza vaccine among house staff. Infect Control Hosp Epidemiol 2003; 24(11):839-844.
Lester RT. Ask, don’t tell-mobile phones to improve HIV care. N Engl J Med. 2013 Nov 7;369(19):1867-8.