cropped-Chow238.jpg
tonychow@mail.ubc.ca
Position(s)
Professor Emeritus, Division of Infectious Diseases
Honorary Staff, Vancouver General Hospital
Research interests

Dr. Chow retired from clinical practice, teaching and administration in July 2006. Since retirement, Dr. Chow has continued to be active in knowledge acquisition and translation of infectious diseases nationally and internationally. He currently serves on the University-Industry Peer Review Committee of the Canadian Institutes of Health Research, and is a consultant to the Therapeutic Products Directorate of Health Canada. He is actively engaged in the development of several clinical practice guidelines for both the Infectious Disease Society of America and the Association of Medical Microbiology and Infectious Diseases of Canada. As well, he serves on the clinical and scientific advisory boards of several bio-pharmaceutical companies for drug discovery, and the editorial boards of several international journals in infection and immunity.

Dr. Chow received his MD degree from the University of Manitoba in 1967. He completed residency training in Internal Medicine in Winnipeg, Manitoba, subspecialty training in Infectious Diseases, and a clinical/research fellowship at Harbor-UCLA, Torrance, CA. He joined UCLA as an Assistant Professor in 1972, and rose to the rank of Associate Professor in 1977. In 1979, he became Professor and founding Head of the Division of Infectious Diseases at UBC and Vancouver Hospital, a position he held until 1993. In 1994, Dr. Chow began a second career in the promotion of translational research, and the development of clinician scientists in Canada. He directed the highly successful MD/PhD Program at UBC, and spearheaded a unique CIHR-funded Strategic Training Program for Translational Research in Infectious Disease (TRID) that actively promotes collaborative research from bench to bedside and population, bridging the 4-pillars of health research. His own research interests include the role of anaerobic bacteria in health and disease, structure/function of staphylococcal superantigens, and the molecular pathogenesis of staphylococcal toxic shock syndrome and other staphylococcal infections. He has held a CIHR operating grant continuously since 1978 until his retirement. He has authored over 350 peer-reviewed papers and book chapters on various clinical syndromes in infectious diseases and their diagnosis, treatment and prevention. He is co-recipient of several US and international patents on the use of the 60 kDa heat shock protein (HSP60) gene sequences as universal targets for infectious disease diagnosis and microbial species identification. He has supervised over 70 postdoctoral clinical and research fellows, 30 summer research and co-operative undergraduate students, and 19 Masters and PhD graduate students.

Publications

Thambirajah AA, Sleigh K, Stiver HG, Chow AW. Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls. Clin Invest Med. 2008 Dec 1;31(6):E319-27.

Kalyan S, Chow AW. Staphylococcal toxic shock syndrome toxin-1 induces the translocation and secretion of high mobility group-1 protein from both activated T cells and monocytes. Mediators Inflamm. 2008;2008:512196.

Reynolds SC, Chow AW. Life-threatening infections of the peripharyngeal and deep fascial spaces of the head and neck. Infect Dis Clin North Am. 2007
Jun;21(2):557-76, viii. Review.

Hull MW, Chow AW. Indigenous microflora and innate immunity of the head and neck. Infect Dis Clin North Am. 2007 Jun;21(2):265-82, v.

Hull MW, Chow AW. An Approach to Oral Infections and Their Management. Curr Infect Dis Rep. 2005 Jan;7(1):17-27.

Hung RW, Chow AW. Dissecting the “end game”: clinical relevance, molecular mechanisms and laboratory assessment of apoptosis. Clin Invest Med. 2004 Dec;27(6):324-44.

Kalyan S, Chow AW. Human peripheral gammadelta T cells potentiate the early proinflammatory cytokine response to staphylococcal toxic shock syndrome toxin-1. J Infect Dis. 2004 May 15;189(10):1892-6.

Solomkin JS, Mazuski JE, Baron EJ, Sawyer RG, Nathens AB, DiPiro JT, Buchman T, Dellinger EP, Jernigan J, Gorbach S, Chow AW, Bartlett J; Infectious Diseases Society of America. Guidelines for the selection of anti-infective agents for complicated intra-abdominal infections. Clin Infect Dis. 2003 Oct 15;37(8):997-1005.

Cameron SB, Stolte EH, Chow AW, Savelkoul HF. T helper cell polarisation as a measure of the maturation of the immune response. Mediators Inflamm. 2003 Oct;12(5):285-92.

Kwok AY, Chow AW. Phylogenetic study of Staphylococcus and Macrococcus species based on partial hsp60 gene sequences. Int J Syst Evol Microbiol. 2003 Jan;53(Pt 1):87-92.

Livesley NJ, Chow AW. Infected pressure ulcers in elderly individuals. Clin
Infect Dis. 2002 Dec 1;35(11):1390-6.

Kwok AY, Wilson JT, Coulthart M, Ng LK, Mutharia L, Chow AW. Phylogenetic study and identification of human pathogenic Vibrio species based on partial hsp60 gene sequences. Can J Microbiol. 2002 Oct;48(10):903-10.

Kum WW, Hung RW, Cameron SB, Chow AW. Temporal sequence and functional implications of V beta-specific T cell receptor down-regulation and costimulatory molecule expression following in vitro stimulation with the staphylococcal superantigen Toxic shock syndrome toxin-1. J Infect Dis. 2002 Feb 15;185(4):555-60.

Wong RS, Chow AW. Identification of enteric pathogens by heat shock protein 60 kDa (HSP60) gene sequences. FEMS Microbiol Lett. 2002 Jan 2;206(1):107-13.